Reproductive Biology & Stem Cell
Ji WU

Ph. D., Professor, Principal Investigator

Ph. D., Peking University Health Science Center

Postdoctoral Fellow, University of Göttingen, Germany

Email:jiwu@sjtu.edu.cn

INTRODUCTION
Dr. Wu has conducted research on development of germ cells in University of Utah, Temple University and Shanghai Jiao Tong University (2004-Present) as a Research Fellow, Associate Scientist, Professor and Chair professor, respectively. She has published over 100 SCI articles and previously served as the chief scientist for the National 973 Program. Currently, Dr. Wu serves as a Section Editor for Reproductive Biology and Endocrinology, Editorial Board member for Cell & Bioscience, etc. Her research finding has been nominated as one of Chinese Universities' Top Ten Achievements in Science and Technology by Ministry of Education. She was awarded Second Prize of the National Natural Science Award of China (rank 1), First Prize of the Shanghai Natural Science Award (rank 1), Leading Talents in Shanghai. 
RESEARCH INTERESTS

Reproductive physiology and epigenetics

Biology of germline stem cells

REPRESENTATIVE PUBLICATIONS

1. Luo Y, Yin M, Mu C, Hu X, Xie H, Li J, Cao T, Chen N*, Wu J*. Fan C*. Engineering female germline stem cells with exocytotic polymer dots. Advanced Materials. 2023; 35: e2210458.

2. Fang Q, Tian G G, Wang Q, Liu M, He L*, Li S*, Wu J*. Ythdf1 phase separation triggers the fate transition of spermatogonial stem cells by activating the ikappab-nf-kappab-ccnd1 axis. Cell Reports. 2023; 42: 112403.

3. Tian GG#, Hou C#, Li J*, Wu J*. Three‐dimensional genome structure shapes the recombination landscape of chromatin features during female germline stem cell development. Clinical and translational medicine. 2022; 12: e927.

4. Hou C, Zhao X, Tian GG*, Wu J*. Stella Regulates the Development of Female Germline Stem Cells by Modulating Chromatin Structure and DNA Methylation. International Journal of Biological Sciences. 2022; 18: 3006.

5. Li X, Zheng M, Xu B, Li D, Shen Y, Nie Y, Ma L*, Wu J*. Generation of offspring-producing 3D ovarian organoids derived from female germline stem cells and their application in toxicological detection. Biomaterials. 2021; 279: 121213.

6. Zhang X-L#, Wu J#, Wang J#, Shen T, Li H, Lu J, Gu Y, Kang Y, Wong C-H, Ngan CY, Shao Z, Wu J* and Zhao X*. Integrative epigenomic analysis reveals unique epigenetic signatures involved in unipotency of mouse female germline stem cells. Genome Biology. 2016; 17: 1-12.

7. Wu C, Xu B, Li X, Ma W, Zhang P, Chen X, Wu J*. Tracing and characterizing the development of transplanted female germline stem cells in vivo. Molecular Therapy. 2017; 25: 1408-1419.

8. Zou K, Yuan Z, Yang Z, Luo H, Sun K, Zhou L, Xiang J, Shi L, Yu Q, Zhang Y, Hou R, Wu J*. Production of offspring from a germline stem cell line derived from neonatal ovaries. Nature Cell Biology. 2009; 11: 631-636.


# Contributed equally to the paper * Corresponding author

Xiaoyong LI

Email:xyli@sjtu.edu.cn

Xiaopeng HU

Email:huxiaopeng2017@sjtu.edu.cn