Neurodegenerative Disease
Dan LI

Ph.D., Assistant professor

Email:lidan2017@sjtu.edu.cn

INTRODUCTION
Dr. Li joined the Bio-X Institutes at Shanghai Jiao Tong University as a principle investigator in 2017. She received her Ph.D. at the Peking University, followed by working at the University of California, Los Angeles, with Dr. David Eisenberg as a postdoctoral fellow.
RESEARCH INTEREST

1. Molecular mechanism of protein phase separation and amyloid aggregation.


2. Protein homeostasis in aging and neurodegenerative diseases.

PUBLICATIONS

26. Jia, C.*, Ma, X.*, Liu, Z., Gu, J., Zhang, X., Li, D.#, Zhang, S.#, Different heat shock proteins bind α-synuclein with distinct mechanisms and synergistically prevent its amyloid aggregation. Frontiers in Neuroscience, 2019 November 1, volume 13, doi: 10.3389/fnins.2019.01124


25. Zhou, H.*, Luo, F.*, Luo, Z.*, Li, D., Liu, C.#, Li, X.#. Programming conventional electron microscopes for solving ultrahigh-resolution structures of small and macro-molecules, Anal. Chem., DOI: 10.1021/acs.analchem.9b01162. 23 Jul 2019.


24. Gui, X., Luo, F., Li, YC, Zhou, H., Qin,Z., Liu, ZY, Gu, JG, Xie, MY, Zhao, K., Dai, B., Shin, WS, He, JH, He, L., Jiang, L., Zhao, ML, Sun, B., Li, XM, Liu, C.#, Li, D.# Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly, Nature Communications, 2019 May 1;10(1):2006.


23. Lu, J.#, Cao, Q.#, Wang, C.#, Zheng, J., Luo, F., Xie, J., Li, Y., Ma, X., He, L., Eisenberg, D., Nowick, J., Jiang, L.#, Li, D.#, Structure-Based Peptide Inhibitor Design of Amyloid-b Aggregation, Frontiers in Molecular Neuroscience, 2019 Mar 4;12:54.


22. Zhang, X., Zhang, S., Zhang, L., Lu, J., Zhao, C., Luo, F., Li, D., Liu, X., Liu, C. , Heat shock protein 104 (HSP104) chaperones soluble Tau via a mechanism distinct from its disaggregase activity, J. Biol. Chem., 2019 Mar 29;294(13):4956-4965.


21. Zhang, S., Wang, C., Lu, J., Ma, X., Liu, Z., Li, D., Liu, Z., Liu, C., In-Cell NMR Study of Tau and MARK2 Phosphorylated Tau, International journal of molecular sciences, 2018.12.26, 20(1): E90.


20. Liu Z, Wang C, Li Y, Zhao C, Li T, Li D, Zhang S, Liu C. Mechanistic insights into the switch of αB-crystallin chaperone activity and self-multimerization. J. Biol. Chem. 2018 Sep 21;293(38):14880-14890.


19. Li, Y.*, Zhao, C.*, Luo, F.*, Liu, Z., Gui, X., Luo, Z., Zhang, X., Li, D.#, Liu, C.#, Li, X.# Amyloid fibril structure of alpha-synuclein determined by cryo-electron microscopy. Cell Research 2018 Sep;28(9):897-903.


18. Li, D.#, Liu, C.#. Better together: a hybrid amyloid signals necroptosis. Cell 2018 Volume 173, Issue 5, p1068–1070, 17 May.


17. Luo, F.*, Gui, X.*, Zhou, H.*, Gu, J., Li, Y., Liu, X., Zhao, M., Li, D.#, Li, X.#, Liu, C.#. Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation. Nature Struct. Mol. Biol. 2018 Apr;25(4):341-346


16. Xie J, Si X, Gu S, Wang M, Shen J, Li H, Shen J, Li D, Fang Y, Liu C, Zhu J. Allosteric inhibitors of SHP2 with therapeutic potential for cancer treatment. J. Med. Chem. 2017, 60 (24): 10205–10219


15. Liu ZY, Zhang SN, Li D, Liu C. A structural view of αB-crystallin assembly and amyloid aggregation. Protein  Pept Lett. 2017. 24(4):315-321.


14.  Wang C, Zhao C, Li D, Tian Z, Lai Y, Diao J, Liu C. Versatile Structures of α-Synuclein. Frontiers in Molecular Neuroscience 2016. Jun 20; 9:48.


13. Dai, B.#, Li, D.#, Xi, W., Luo, F., Zhang, X., Zou, M., Cao, M., Hu, J., Wang, W., Wei, G., Zhang, Y.*, Liu, C.*Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier. PNAS 2015 Mar 10;112(10):2996-3001.


12. Li, D., Jones, E.M., Sawaya, M.R., Furukawa, H., Luo, F., Ivanova, M., Sievers, S.A., Wang, W., Yaghi, O.M., Liu, C., Eisenberg, D.S. Structure-based design of functional amyloid materials. JACS, 2014 Dec 31;136(52):18044-18051.


11. Li LF, Nan J, Li D, Brostromer E, Wang Z, Liu C, Hou Q, Fan X, Ye Z, Su XD. Structural genomics studies of human caries pathogen Streptococcus mutans. J. Struct. Funct. Genom. 2014, DOI 10.1007/s10969-014-9172-3.


10. Korman, TP*, Sahachartsiri, B*, Li, D., Eisenberg, D., Bowie, J.U. A synthetic biochemistry system for the in vitro production of isoprene from glycolysis intermediates. Protein Science 2014 May;23(5):576-85.


9.  Li, D.#, Hiroyasu, F.#, Deng, H., Liu, C., Yaghi, O.M., Eisenberg, D.S. Designed amyloid fibers as materials for selective carbon dioxide capture. PNAS  2014, 111, 191-196.


8.  Li D*, Fu TM*, Nan J, Liu C, Li LF and Su XD. Structural basis for the autoinhibition of the C-terminal kinase domain of human RSK1.  Acta Crystallogr. Sect. D-Biol. Crystallogr. 2012, 68, 680-685.


7.  Hu J, Li D, Su XD, Jin C, Xia B. Solution structure and conformational heterogeneity of acylphosphatase from Bacillus subtilis. FEBS Lett. 2010, 584, 2852-2856.


6.  Li D, Liu C, Liang YH, Li LF, Su XD. Crystal structure of B. subtilis YjcG characterizing the YjcG-like group of 2H phosphoesterase superfamily. Proteins 2008, 72, 1071-1076.


5.  Liu C*, Li D*, Liang YH, Li LF, Su XD. Ring-opening mechanism revealed by crystal structures of NagB and its ES intermediate complex. J. Mol. Biol. 2008, 379, 73-81.


4.   Fu TM*, Li D*, Nan J, Li L, Xue Y, Su XD. Protein preparation, crystallization and preliminary X-ray analysis of the C-terminal domain of human RSK1 serine/threonine protein kinase. Acta Crystallogr. F-Struct. Biol. Cryst. Commun. 2007, 63, 1026-1028.


3.  Hu GJ, Li LF, Li D, Liu C, Wei SC, Liang YH, Su XD. Protein preparation and preliminary X-ray crystallographic analysis of a putative glucosamine 6-phosphate deaminase from Streptococcus mutants. Acta Crystallogr. F-Struct. Biol. Cryst. Commun.2007, 63, 809-811.


2.  Liu C*, Li D*, Hederstedt L, Li L, Liang YH, Su XD. Preparation, crystallization and preliminary X-ray analysis of protein YtlP from Bacillus subtilis. Acta Crystallogr. F-Struct. Biol. Cryst. Commun. 2006, 62, 967-969.


1.   Li D, Chan C, Liang YH, Zheng X, Li L, Su XD. Preparation, crystallization and preliminary X-ray analysis of YjcG protein from Bacillus subtilis. Acta Crystallogr. F-Struct. Biol. Cryst. Commun. 2005, 61, 496-498.