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李胜天

博士, 副教授, 研究组长, 博导

学士 (1985-1991) 白求恩医科大学
博士 (1996-2000)日本东京大学医学系研究科
博士后 (2000-2005)日本冈山大学、日本东京大学医学科学研究所

Email:lstian@sjtu.edu.cn

实验室网址:lstlab.sjtu.edu.cn

个人介绍

上海交通大学Bio-X研究院副教授,博士生导师,上海市浦江人才,上海市科技进步二等奖获得者。白求恩医科大学临床医学学士,日本东京大学神经生物学博士。主要专注于利用大、小鼠模型研究癫痫、抑郁症、帕金森氏病等精神神经系统疾病的致病机理和研发治疗手段。发表SCI论文46篇,被2076篇论文引用。h-index: 24(截止2022年9月,Scopus Author ID: 36063540000; ORCID: 0000-0002-2836-3802)。获得二项发明专利授权。主持多项国家自然基金、上海市科委自然科学基金、以及与跨国公司的横向合作项目。



研究方向

癫痫的早期发病机制及干预策略;针刺的穴位激活机制研究。

代表性论文

近五年发表的代表性论文 (CA corresponding author; # co-first author)

1.      Wang T, Zhu G, Qin LY, Wang Q, She C, Xu DS, Hu WW, Luo KH, Lei Y, Gong YL, Ghosh A, Ma DN, Ding CL, Wang BY, Guo Y, Ma SS, Hattori M, Takagi Y, Ara K, Higuchi K, Li XW, He L, Bai WZ, Ishida K, Li STCA. (2021) Kininogen-nitric oxide signaling at nearby nonexcited acupoints after long-term stimulation. JID Innovations, 1:100038. Doi: https://doi.org/10.1016/j.xjidi.2021.100038.

2.      Hou YF, Shan C, Zhuang SY, Zhuang QQ, Ghosh A, Zhu KC, Kong XK, Wang SM, Gong YL, Yang YY, Tao B, Sun LH, Zhao HY, Guo XZ, Wang WQ, Ning G, Gu YYCA, Li STCA, Liu JMCA. (2021) Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson's disease. Microbiome, 9(1):34.

3.      Shan C, Gong YL, Zhuang QQ, Hou YF, Wang SM, Zhu Q, Huang GR, Tao B, Sun LH, Zhao HY, Li STCA, Liu JMCA. (2019) Protective effects of β-nicotinamide adenine dinucleotide against motor deficits and dopaminergic neuronal damage in a mouse model of Parkinson’s disease, Progress in Neuropsychopharmacology & Biological Psychiatry, 94, 109670.

4.      Wu Z, Huo QW, Ren L, Dong FP, Feng MY, Wang Y, Bai YT, Luscher B, Li ST, Wang GL, Ceng L, Wang Y, Wu GY, Chen G. (2019) Gluconate suppresses seizure activity indeveloping brains by inhibiting CLC-3 chloride channels, Mol Brain, 12:50, DOI: 10.1186/s13041-019-0465-0.

5.      Shan C, Guo XZ, Wang SM, Hou YF, Li STCA, Liu JMCA (2019) Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders, Mol Brain, 12:23, DOI: 10.1186/s13041-019-0444-5.

6.      Zou J, Wang XX, Huang LG, Liu J, Kong YY, Li STCA, Lu QCCA. (2019) Kininogen level in the cerebrospinal fluid may be a potential biomarker for predicting epileptogenesis, Frontiers in Neurology, 31 January 2019, DOI: 10.3389/fneur.2019.00037.

7.      Zhang DQ#, Li HD#, Sun jf, Hu WW, Jin W, Li STCA, Tong SBCA. (2019) Antidepressant-like Effect of Low-intensity Transcranial Ultrasound Stimulation, IEEE Transactions on Biomedical Engineering, 66(2),8375644, 411-420

8.      Guo XZ, Shan C, Hou YF, Zhu G, Tao B, Sun LH, Zhao HY, Ning GCA, Li STCA, Liu JMCA (2018) Osteocalcin ameliorates motor dysfunction in a 6-hydroxydopamine hydrobromide-induced Parkinson’s disease rat model through AKT/GSK3β signaling, Frontiers in molecular neuroscience, 11:343.

9.      Chen XM#, Wang S#, Zhou Y#, Han YF#Li ST#, Xu Q, …, Li WD, Chen CD (2018). PHF8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway. Nature Communications, 9:114.

10.   Liu J#, Yang BM#, Zhou P, Kong YY, Hu WW, Zhu G, Ying WH, Li WDCA, Wang YCA, Li STCA. (2017) Nicotinamide adenine dinucleotide suppresses epileptogenesis at an early stage. Scientific Reports, December 7:7321.

11.   Yang Q#, Zhu G#, Ju JG, Liao ZH, Xiao YX, Zhang Y, Luo JHCA, Li STCA. (2017) Extrasynaptic NMDA receptor dependent long-term potentiation of hippocampal CA1 pyramidal neurons. Scientific Reports, 7(1), June 2017. 03287

12.   Guo XZ, Liu TT, Zhao DD, Wang XF, Liu DM, He Y, Shan C, Kong YY, Hu WW, Tao B, Sun LH, Zhao HY, Li STCA, Liu JMCA. (2017) FGF18 protects against 6-hydroxydopamine-induced nigrostriatal damage in a rat model of Parkinson's disease. Neuroscience, 356:229-241.

13.   Kong YY, Wang T, Wang R, Ma YC, Song SS, Liu J, Hu WW, Li STCA. (2017) Inhalation of Roman Chamomile Essential Oil Attenuates Depressive-Like Behaviors in Wistar Kyoto Rats. SCIENCE CHINA Life Sciences. 60(6)647-655.