本课题组聚焦听觉感受与听力障碍相关研究。获得国家自然科学基金、上海市东方学者、香港研究资助局等计划支持。主要研究成果以通讯作者发表在Developmental Cell、Nature Communications、PNAS等杂志上。

1. 内耳毛细胞发育过程

2. 声音感受的机械信号转导过程

1. Wu S#, Lin L#, Hu Q#, Yao X#, Wang H#, Liu S, Liu Q, Xi Y, Lin Y, Gong J, Hu R, Zhan W, Luo Y, He G, Liu Z, Xiong W, Wang Q*, Xu Z*, Bai F*, and Lu Q*. Mechano-electrical transduction components TMC1-CIB2 undergo a Ca2+-induced conformational change linked to hearing loss. Developmental Cell. 2025

2. Feng M#, Wei X#, Zheng X, Liu L, Lin L, Xia M, He G*, Shi Y*, Lu Q*. Decoding Missense Variants by Incorporating Phase Separation via Machine Learning. Nat Commun. 2024

3. Li N#, Liu S#, Zhao D#, Du H, Xi Y, Wei X, Liu Q, Müller U, Lu Q*, Xiong W*, Xu Z*. Disruption of Cdh23 exon 68 splicing leads to progressive hearing loss in mice by affecting tip-link stability. Proc Natl Acad Sci U S A. 2024

4. Ruan K*, Bai G*, Fang Y*, Li D*, Li T*, Liu X*, Lu B*, Lu Q*, Songyang Z*, Sun S*, Wang Z*, Zhang X*, Zhou W*, Zhang H*. Biomolecular condensates and disease pathogenesis. Sci China Life Sci. 2024

5. Song X#, Hu R#, Chen Y#, Xiao M, Zhang H, Wu S*, Lu Q*. The structure of TRAF7 coiled-coil trimer provides insight into its function in zebrafish embryonic development. J Mol Cell Biol. 2024

6. Wang H#, Du H#, Ren R, Du T, Lin L, Feng Z, Zhao D, Wei X, Zhai X, Wang H, Dong T, Sun JP, Wu H, Xu Z*, Lu Q*. Temporal and spatial assembly of inner-ear hair-cell ankle-link condensate via phase separation. Nat Commun. 2023

7. Ren D#, Wei X#, Lin L#, Yuan F, Bi Y, Guo Z, Liu L, Ji L, Yang X, Han K, Yang F, Wu X, Li X, Yi Z, Xu Y, Cai C, Wang P, Li W, He L, Zhou D, Yu T, Shi Y, Lu Q*, He G*. A novel heterozygous missense variant of the ARID4A gene identified in Han Chinese families with schizophrenia-diagnosed siblings that interferes with DNA-binding activity. Mol Psychiatry. 2022

8. Dai Y#, Idorn M#, Serrero MC, Pan X, Thomsen EA, Narita R, Maimaitili M, Qian X, Iversen MB, Reinert LS, Flygaard RK, Chen M, Ding X, Zhang BC, Carter-Timofte ME, Lu Q, Jiang Z, Zhong Y, Zhang S, Da L, Zhu J, Denham M, Nissen P, Mogensen TH, Mikkelsen JG, Zhang SY, Casanova JL, Cai Y*, Paludan SR*. TMEFF1 is a neuron-specific restriction factor for herpes simplex virus. Nature. 2024

9. Mao Y*, Harvey WT, Porubsky D, Munson KM, Hoekzema K, Lewis AP, Audano PA, Rozanski A, Yang X, Zhang S, Yoo D, Gordon DS, Fair T, Wei X, Logsdon GA, Haukness M, Dishuck PC, Jeong H, Del Rosario R, Bauer VL, Fattor WT, Wilkerson GK, Mao Y, Shi Y, Sun Q, Lu Q, Paten B, Bakken TE, Pollen AA, Feng G, Sawyer SL, Warren WC, Carbone L, Eichler EE*. Structurally divergent and recurrently mutated regions of primate genomes. Cell. 2024

10. Huang Wang#, Dange Zhao#, Haibo Du#, Xiaoyan Zhai, Shaoxuan Wu, Lin Lin, Zhigang Xu*, Lu Q*; Deafness-related protein PDZD7 forms complex with the C-terminal tail of FCHSD2. Biochem J. 2022

11. Lin L#, Wang H#, Ren D#, Xia Y, He G*, Lu Q*. Structure and Membrane Targeting of the PDZD7 Harmonin Homology Domain (HHD) Associated With Hearing Loss. Front Cell Dev Biol. 2021

12. Lin L#, Shi Y#, Wang M, Wang C, Lu Q, Zhu J*, Zhang R*. Phase separation-mediated condensation of Whirlin-Myo15-Eps8 stereocilia tip complex. Cell Rep. 2021

13. Li J#, He Y#, Lu Q*, Zhang M*, Mechanistic Basis of Organization of the Harmonin/USH1C-Mediated Brush Border Microvilli Tip-Link Complex, Developmental Cell. 2016

14. Lu Q#, Li J#, Ye F, Zhang M*. Structure of myosin-1c tail bound to calmodulin provides insights into calcium-mediated conformational coupling. Nat Struct Mol Biol. 2015 

15. Lu Q, Li J, Zhang M*. Cargo recognition and cargo-mediated regulation of unconventional myosins. Acc Chem Res. 2014

16. Lu Q#, Ye F#, Wei Z, Wen Z, Zhang M*. Antiparallel coiled-coil-mediated dimerization of myosin X. Proc Natl Acad Sci U S A. 2012