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Can Li
Ph.D., Associate Professor, Principal Investigator
B.S. (1992-1996) Nanjing University
Ph.D. (1998-2004) Institute of Biochemistry and Cell Biology
Post-doc (2005-2007) Eccles Institute of Human Genetics University of Utah
Email: lican@live.cn |
INTRODUCTION:
Apart from providing the material for genetic information storage, DNA has also been regarded as a useful building block in the field of nanotechnology, which is known as DNA nanotechnology. Based on the Watson-Crick base-pairing and the famous double helical structure, a library of DNA 2D or 3D nanostructures has been designed, constructed and characterized, by either tile-based or origami-based self-assembly. More significantly, other molecules/nanomaterials can be organized on those DNA ensembles to achieve highly ordered arrays or specific patterns in nanometer spatial resolution.
REPRESENTATIVE PUBLICATIONS:
Zhang Z, Wang Y, Fan C*, Li C, Li Y, Qian L, Fu Y, Shi Y, Hu J, He L*. Asymmetric DNA origami for spatially addressable and index-free solution-phase DNA chips. Adv Mater. 2010 ;22(24):2672-5. Zhang Z, Zeng D, Ma H, Feng G, Hu J, He L*, Li C*, Fan C*. A DNA-Origami Chip Platform for Label-Free SNP Genotyping Using Toehold-Mediated Strand Displacement. Small. 2010;6(17):1854-8. Zhang Z, Fu, Y, Feng G, Li C*, Fan C, He, L*. Self-assembly-based Structural DNA nanotechnology. CURRENT ORGANIC CHEMISTRY. 2011;15(4):534-547. Li C, Wu Q*. Adaptive evolution of multiple-variable exons and structural diversity of drug-metabolizing enzymes. BMC Evolutionary Biology. 2007; 7:69. Li C, Zhang Y, Ying K, Liang X, Han B. Sequence variations of simple sequence repeats on chromosome 4 in two subspecies of the Asian cultivated rice. Theoretical and Applied Genetics. 2004; 108: 392-400. Feng Q,..... Li C, ...... Han B. Sequence and analysis of rice chromosome 4. Nature. 2002; 420: 316-320. (Nature Publishing Group Journal)
# Contributed equally to the paper * Corresponding author
DNA Nanostructure
Nanobiotechnology
Nanomedicine
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