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Lun YANG
Principal Investigator (2007 - 2009) Shanghai Jiaotong University
Investigator (2009 - Present) US. Food and Drug Administration
Email: ylemyang#gmail.com
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INTRODUCTION:
We dedicate our passion to developing systematic methodology through data-mining, literature-mining and in silico simulation for both hypothesis generation and biology discovery in the area of translational medicine.
Our ongoing research is to identify unexpected genetic factors involved in drug safety and drug efficacy through 1) utilizing the idiosyncracy of drugs sharing the same adverse reaction or therapeutic efficacy, and 2) evaluating the importance of some particular genes in the context of complex and fuzzy physiology environment symbolized rationally and quantitatively by weighted biological networks.
We do not give up the ambition to translate our methodologies into commercially available solutions or open source platforms, and collaborations at any level will be welcomed. We are expecting talents from all around the world to have further discussion, cooperation or coalition on all of the topics mentioned above, finally delivering personalized medicine to the public.
News reports of our group in U.S. media:
Sample publications of our studies:
# Equal contribution; * Corresponding authorship
- Heng Luo#, Jian Chen#, Leming Shi, Mike Mikailov, Huang Zhu, Kejian Wang, Lin He* and Lun Yang#*. DRAR-CPI: a server for identifying drug repositioning potential and adverse drug reactions via the chemical-protein interactome. Nucleic Acids Research. 2011;1(7). doi:10.1093/nar/gkr299. service available at http://cpi.bio-x.cn/drar/
- Lun Yang#*, Kejian Wang#, Jian Chen, Anil G Jegga, Heng Luo, Leming Shi, Chunling Wan, Xizhi Guo, Shengying Qin, Guang He, Guoyin Feng, Lin He*. Exploring Off-Targets and Off-Systems for Adverse Drug Reactions via Chemical-Protein Interactome ！ Clozapine-Induced Agranulocytosis as a Case Study. PLoS Computational Biology. 2011;7(3):e10002016. doi:10.1371/journal.pcbi.1002016
- Lun Yang*, Jian Chen, Leming Shi, Michael P Hudock, Kejian Wang, Lin He*. Identifying unexpected therapeutic targets via chemical-protein interactome. PLoS One. 2010;5(3):e9568. doi:10.1371/journal.pone.0009568
- Lun Yang*, Jian Chen, Lin He*. Harvesting Candidate Genes for Serious Adverse Drug Reactions from a Chemical-Protein Interactome. PLoS Computational Biology. 2009;5(7):e1000441. doi:10.1371/journal.pcbi.1000441
- Lun Yang*, Langlai Xu, Lin He*. A CitationRank Algorithm Inheriting Google Technology Designed to Highlight Genes Responsible for Serious Adverse Drug Reaction. Bioinformatics. 2009;25(17):2244-50. doi:10.1093/bioinformatics/btp369. service available at http://gengle.bio-x.cn/SADR/
- Lun Yang#*, Heng Luo#, Jian Chen, Qinghe Xing, Lin He*. SePreSA, a server for the prediction of populations susceptible to serious adverse drug reactions implementing the methodology of a chemical-protein interactome. Nucleic Acids Research. 2009;37(Web Server issue):W406-12. doi:10.1093/nar/gkp312. service available at http://sepresa.bio-x.cn/
Our servers:
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