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Xizhi GUO
Ph.D., Professor, Principal Investigator
B.S. (1993-1997) Wuhan University
Ph.D. (1997-2002) Institute of Plant Physiology and Ecology, SIBS, CAS
Post-doc (2003-2007) National Human Genome Research Institute, NIH
Email: xzguo2005@yahoo.com |
INTRODUCTION:
Dr Guo is a winner of Young Investigator of ASBMR (2005), Fellow Award for Research Excellence in NIH (2005), Shanghai Pujiang Talent (2008) and Chief Scientist of the project of State Key Development Program for Basic Research of China with theme of ¡°The molecular mechanisms underlying skeletal development and disorders¡± (Grant No. 2007CB947300).
RESEARCH INTERESTS:
The mechanisms underlying skeletal development; Developing therapeutic strategies for bone diseases including osteoporosis and osteoarthritis; the role of miRNA in osteogenesis; the therapeutic exploring of mesenchymal stem cell in bone diseases treatment.
REPRESENTATIVE PUBLICATIONS:
Guo X, Mak KK, Taketo MM, Yang Y*. The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturation. PLoS One. 2009; 26;4(6):e6067. Lin C#, Jiang X#, Dai Z, Guo X, Weng T, Wang J, Li Y, Feng G, Gao X*, He L*. Sclerostin Mediates Bone Response to Mechanical Unloading via Antagonizing Wnt/beta-Catenin Signaling. J Bone Miner Res. 2009; 24(10):1651-61. Zhou J, Meng J, Guo S, Gao B, Ma G, Zhu X, Hu J, Xiao Y, Lin C, Wang H, Ding L, Feng G, Guo X, He L*. IHH and FGF8 coregulate elongation of digit primordia. Biochem Biophys Res Commun. 2007; 363(3):513-8. Day TF#, Guo X#, Garrett-Beal L, Yang Y*. Wnt/¦Â-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis. Developmental Cell. 2005; 8 (5): 739-750. Guo X#, Day TF#, Jiang X, Garrett-Beal L, Topol L, Yang Y*. Wnt/-catenin signaling is sufficient and necessary for synovial joint formation. Gene & Development. 2004; 18:2404-2417.
# Contributed equally to the paper¡¡
* Corresponding author
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