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Signal Transduction in Skeletal stem cells

 

Baojie LI

Ph.D., Professor, Principal Investigator

Email: libj@sjtu.edu.cn

 

 

 INTRODUCTION:

  Dr. Li joined the Bio-X Institutes at Shanghai Jiao Tong University as a Changjiang Scholar in 2009 after working at The Institute of Molecular and Cell Biology, Singapore as an assistant professor and associate professor from 2001-2009. He has received the Career Enhancement Award of ASBMR and now serves as an associate editor of BMC Developmental Biology as well as editorial board members for several other journals. His research is supported by NSFC, 973 and Shanghai Pujiang program.

 

RESEARCH INTERESTS:

  Mesenchymal Stem Cell self-renewal, differentiation, and aging; Bone development and remodeling and pathogenesis of bone-related diseases; DNA damage response, aging and tumorigenesis.

 

REPRESENTATIVE PUBLICATIONS:

1. Keng Po Lai, Wai Fook Leong, Jenny Fung Ling Chau, Deyong Jia, Li Zeng, Huijuan Liu, Aijun Hao, Lin He, Hongbing Zhang, David Meek, Chakradhar Velagapudi, Samy L. Habib, and Baojie Li* (2010). S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response. EMBO J., 29(17):2994-3006

2. Gang Ma, Lili Li, Yuanyu Hu, Bijin Au, Lin He and Baojie Li* (2012).  Atypical Atm-p53 interaction in osteogenesis is mediated by Smad1 signaling. J Mol Cell Biol, 4(2): 118-120.

3. Jenny Chau, Yuanyu Hu,  Jianhe Wang, Zhi Liu, Bi Jin Au, Yuji Mishina, Ye-Guang Chen, Christine Biondi, Elizabeth Robertson, Yue-Zheng Du, Dong Xie, Xueying Wang, Qiang Yu, and Baojie Li* (2012).  A crucial role for BMP-Smad1 signaling in the DNA damage response. Nature Communications, 2012 May 15; 3:836.

4. Kua HY, Liu H, Leong WF, Li L, Jia D, Ma G, Hu Y, Wang X, Chau JF, Chen YG, Mishina Y, Boast S, Yeh J, Xia L, Chen GQ, He L, Goff SP, and Baojie Li *(2012) c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16(INK4a) expression. Nature Cell Biology. 14(7):727-37

5. Huijuan Liu, Deyong Jia, Jenny Chau, Lin He and Baojie Li* (2013). p53 regulates neural stem cell self-renewal and differentiation via BMP-Smad1-Id1 pathway.  Stem Cell Dev. 15;22(6):913-27.

6. Hao Jia, Jenny Fang Ling Chau, Qian Cong, and Baojie Li* (2014).  A critical role for p57Kip2 in the DNA damage response.  Oncogene.  2014 Sep 8. doi: 10.1038/onc.2014.287. [Epub ahead of print].

7. Bing Qi1 , Qian Cong 2 , Ping Li2, Gang Ma2, Xizhi Guo2, Min Xie3, Michael D. Schneider4, Huijuan Liu2, #, and Baojie Li* (2014) Ablation of Tak1 in monocyte leads to defects in skeletal growth and bone remodeling in mice.  Scientific Reports, Nov 24; 4:7158.

8. Xinsen Ruan1,*, Qiao Zuo2,*, Jenny Chua3, Hao Jia1, Jinlin Lin1, Xuechun Xia1, Huijuan Liu1, Samy L. Habib4, Chuangang Fu2, 5, and Baojie Li*.  p53 deficiency-induced Smad1 up-regulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers.  J Mol Cell Biol. 2015 Mar 10. pii: mjv015. [Epub ahead of print]

 

# Contributed equally to the paper * Corresponding author

 

   

 

 

Huijuan LIU

Ph.D., Associate Research Fellow, Master Mentor

Email: liumiaomiao333@163.com

 

 

INTRODUCTION:

  Dr. LIU's  research has been sponsored by NSCF and 973 program.

 

RESEARCH INTERESTS:

  The mechanism of Mesenchymal stem cell differentiation and proliferation in vivo. The regulation of DNA damage response signaling and tumorigenesis.   

 

REPRESENTATIVE PUBLICATIONS:

1.Kua HY#, Liu Huijuan#, Leong WF, Li L, Jia D, Ma G, Hu Y, Wang X, Chau JF, Chen YG, Mishina Y, He L, Goff SP, Li B. c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16(INK4a) expression. Nat Cell Biol. 2012;24;14(7):727-37.    

2.Liu Huijuan, Jia D, Li A, Chau J, He D, Ruan X, Liu F, Li J, He L, Li B. p53 regulates neural stem cell proliferation and differentiation via BMP-Smad1 signaling and Id1. Stem Cells Dev. 2013;22(6):913-27.

3.Liu Huijuan, Li B. p53 control of bone remodeling. J Cell Biochem. 2010;111(3):529-34.

4.Liu Huijuan, Jia D, Fu J, Zhao S, He G, Ling EA, Gao J, Hao A. Effects of granulocyte colony-stimulating factor on the proliferation and cell-fate specification of neural stem cells.  Neuroscience. 2009;164(4):1521-30.

5.Lai KP, Leong WF, Chau JF, Jia D, Zeng L, Liu Huijuan, He L, Hao A, Zhang H, Meek D, Velagapudi C, Habib SL, Li B. S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response. EMBO J. 2010;29(17):2994-3006.

6.Ma G, Li L, Hu Y, Chau JF, Au BJ, Jia D, Liu Huijuan, Yeh J, He L, Hao A, Li B. Atypical Atm-p53 genetic interaction in osteogenesis is mediated by Smad1 signaling. J Mol Cell Biol. 2012;4(2):118-20.

7.Jia DY#, Liu huijuan#, Wang FW, Liu SM, Ling EA, Liu K, Hao AJ. Folic acid supplementation affects apoptosis and differentiation of embryonic neural stem cells exposed to high glucose. Neurosci Lett. 2008;440(1):27-31.

# Contributed equally to the paper * Corresponding author

 

 

Xuechun XIA

Ph.D., Assistant Research Fellow, Master Mentor

Email: xuechun.xia@sjtu.edu.cn

INTRODUCTION:

         Dr. Xia received his B.S. in Biochemistry from Wuhan University and M.S. from Zhejiang University and Ph.D. from Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences. He got postdoctoral training in University of Texas Health Science Center at San Antonio and University of Florida.

 

RESEARCH INTERESTS:

        Basic and preclinical research in osteoporosis. Osteogenic differentiation of mesenchymal stromal cells.

 

REPRESENTATIVE PUBLICATIONS:

1.Batra N, Burra S, Siller-Jackson AJ, Gu S, Xia X, Weber GF, DeSimone D, Bonewald LF, Lafer EM, Sprague E, Schwartz MA, Jiang JX. Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels. Proc Natl Acad Sci U S A. 2012, 109(9): 3359-64.

2.Shalhoub V, Shatzen EM, Ward SC, Davis J, Stevens J, Bi V, Renshaw L, Hawkins N, Wang W, Chen C, Tsai MM, Cattley RC, Wronski TJ, Xia X, Li X, Henley C, Eschenberg M, Richards WG. FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality. J Clin Invest. 2012, 122(7): 2543-53.

3.Aguirre JI, Akhter MP, Kimmel DB, Pingel J, Xia X, Williams A, Jorgensen M, Edmonds K, Lee JY, Reinhard MK, Battles AH, Kesavalu L, Wronski TJ. Enhanced alveolar bone loss in a model of non-invasive periodontitis in rice rats. Oral Dis. 2012, 18(5): 459-68.

4.Halloran BP, Wronski TJ, Herzen DV, Chu V, Xia X, Pingel JE, Smith B. Dietary dried plum increases bone mass in adult and aged mice. Journal of Nutrition, 2010, 140(10): 1781-1787.

5.Xia X, Kar R, Gluhak-Heinrich J, Yao W, Lane NE, Bonewald LF, Biswas SK, Lo WK, Jiang JX. Glucocorticoid induced autophagy in osteocytes. Journal of Bone and Mineral Research, 2010, 25(11): 2479–2488.

6.Xia X, Batra N, Shi Q, Bonewald LF, Sprague E, Jiang JX. Prostaglandin promotion of osteocyte gap junction function through transcriptional regulation of connexin 43 by glycogen synthase kinase 3/beta-catenin signaling. Molecular and Cellular Biology, 2010, 30(1): 206-219.

7.Xia X, Hou F, Li J, Ke Y, Nie H. Two novel proteins bind specifically to trichosanthin on choriocarcinoma cell membrane. Journal of Biochemistry, 2006, 139: 725-731.

8.Xia X, Hou F, Li J, Nie H. Ribosomal protein L10a, a bridge between trichosanthin and the ribosome. Biochemical and Biophysical Research Communications, 2005, 336: 281-286.

# Contributed equally to the paper * Corresponding author

 

 

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