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Neurobiology & Animal Model for Neuropsychiatric Disorders

 

Weidong LI

Ph. D., Professor, Principal Investigator
Email: weidongbiox@gmail.com

 

INTRODUCTION:
       Dr. Li Is a professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning; Shanghai “Shu Guang” Scholar; Project Leader of the National Basic Research Program of China (973 Program). Dr. Li won several prestigious awards, including Young Investigator Awards of NARSAD and CTF.

 

RESEARCH INTERESTS:
        Pathogenesis of Schizophrenia and Depression; Mechanisms and therapeutics of cognitive deficits in Neurofibromatosis 1(NF1); Animal models of neuropsychiatric disorders; Molecular cognition; iPS and brain tumor.

 

REPRESENTATIVE PUBLICATIONS:
1. Zhou M#, Li W *#, Huang S, Song J, Kim JY, Tian X, Kang E, Sano Y, Liu C, J. Balaji, Wu S, Zhou Y, Zhou Y, Parivash SN, Ehninger D, He L, Song H, Ming G-L, Silva AJ*. mTOR Inhibition Ameliorates Cognitive and Affective Deficits Caused by Disc1 Knockdown in Adult-Born Dentate Granule Neurons, Neuron, 20;77(4):647-754,2013 Feb
2. Li W *#,Zhou Y#, Tian X#, Kim T, Ito N, Watanabe K, Tsuji A, Niimi K, Aoyama Y, Arai T, Takahashi E*, New ataxic tottering-6j mouse allele containing a Cacna1a gene mutation, PLoS ONE,7(8): e44230, 2012 Aug
3. Yuan A,Yi Z,Sun J,Du Y, Yu T, Zhang C, Liu Y, Zhou Y, Liu D, Li H, Xu Y, Cheng Z, Li W *,Yu S*.Effect of SOX10 gene polymorphism on early onset schizophrenia in Chinese Han population,Neurosci Lett,521(2):93-7, 2012 Jul 19
4. Ehninger D, Li W, Fox K, Stryker M.P, Silva A.J, Reversing neurodevelopmental disorders in adults, Neuron, 60(6):950-960,2008 Dec 26
5. Li W, Zhou Y, Jentsch J. D, Ehninger D, Brown R.A.M, Tian X , Hennah W, Peltonen L, Lönnqvist J, Huttunen M.O, Kaprio J, Trachtenberg J.T, Silva A. J, Cannon T. D., Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice, PNAS,104(46):18280-18285,2007 Nov 13
6. Li W, Y Cui, Kushner S.A, Brown R.A.M, Frankland P. W, Jentsch J. D, Cannon T. D, Silva A. J, TheHMG-CoA reductase inhibitor, lovastatin, reverses the learning and attention deficits in a mouse model of Neurofibromatosis Type 1., Curr Biol., 15(21), pp 1961-1967, 2005/11/8
7. Li W, Okano A, Tian QB, Nakayama K, Furihata T, Nawa H, Suzuki T., Characterization of a novel synGAP isoform, synGAP-beta., J Biol Chem., 276((24)), pp 21417-21424, 2001/6/15
 

# Contributed equally to the paper * Corresponding author
 
 
 
 

Ying ZHOU

Ph. D., Assistant Research Fellow

Email: emilyzhou511@126.com

 

INTRODUCTION:
        Dr. Zhou joined the laboratory of molecular cognition animal modeling of neuropsychiatric disorders as an assistant research fellow in 2013. Her project was sponsored by National Natural Science Foundation of China. She served as a young investigator in several projects , including National 973 Program, the national major scientific instruments development and NSFC.

 

RESEARCH INTERESTS:

        Animal modeling approaches to research the mechanism of neuropsychiatric disorders; Molecular cognition; iPS and brain tumor.

 

REPRESENTATIVE PUBLICATIONS:

1. Li W#, Zhou Y#, Tian X#, Kim TY, Ito N, Watanabe K, Tsuji A, Niimi K, Aoyama Y, Arai T, Takahashi E. New ataxic tottering-6j mouse allele containing a Cacna1a gene mutation. PLoS One . 2012;7(8):e44230.

2. Tang M, Wang Z, Zhou Y, Xu W, Li S, Wang L, Wei D, Qiao Z. A novel drug candidate for Alzheimer's disease treatment: gx-50 derived from Zanthoxylum bungeanum.J Alzheimers Dis. 2013 Jan 1;34(1):203-13.

3. Yuan A, Yi Z, Sun J, Du Y, Yu T, Zhang C, Liu Y, Zhou Y, Liu D, Li H, Xu Y, Cheng Z, Li W, Yu S. Effect of SOX10 gene polymorphism on early onset schizophrenia in Chinese Hanpopulation.Neurosci Lett. 2012 Jul 19;521(2):93-7.

4. Zhou Y, Wang ZX, Tang MP, Yao CJ, Xu WJ, Wang LY, Qiao ZD.Nicotine induces cyclooxygenase-2 and prostaglandin E(2) expression in human umbilical vein endothelial cells.Int Immunopharmacol. 2010 Apr;10(4):461-6.

 # Contributed equally to the paper * Corresponding author

 

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