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神经发育与信号转导研究组

 

朱金伟

博士,上海交通大学特别研究员,课题组长,博士生导师

学    士 (2001-2005) 南开大学

博    士 (2005-2010) 复旦大学

博士后(2010-2013) 香港科技大学

副研究员(2013-2019)中科院上海生物化学与细胞生物学研究所

Email: jinwei_zhu@hotmail.com   

 

 

个人介绍:
        长期致力于神经发育及信号转导的生物化学与结构生物学研究;主持国家自然科学基金面上项目(2014, 2017),国家自然科学基金大科学装置联合基金培育项目(2015),上海市青年科技英才“扬帆计划”(2014),科技部重点研发计划子任务(2018)。以第一作者或通讯作者在Nat Rev Neurosci,Mol Cell,Nat Commun,EMBO J,Cell Rep,Cell Res,J Am Soc Nephrol,Structure,JBC,Biochem J等国际知名期刊发表多篇学术论文。担任国家自然科学基金评审。

   

研究方向:

1. 神经发育及信号转导的生化与结构基础;

2. 神经疾病相关重要蛋白复合物的组装机制

 

代表性论文:

 

1. Lin L, Shi Y, Wang M, Wang C, Zhu J*, and Zhang R*. (2019) Rab35/ACAP2 and Rab35/RUSC2 Complex Structures Reveal Molecular Basis for Effector Recognition by Rab35 GTPase. Structure 27(5):729-740. (Lead contact).

 

2. Weng Z, Situ C, Lin L, Wu Z, Zhu J*, and Zhang R* (2019) Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds. Nat Commun 10(1):51. (Lead contact).

 

3. Weng Z, Shang Y, Ji Z, Ye F, Lin L, Zhang R* and Zhu J* (2018) Structural basis of highly specific interaction between Nephrin and MAGI1 in slit diaphragm assembly and signaling. J Am Soc Nephrol 29(9):2362-2371.

 

4. Weng Z, Shang Y, Yao D, Zhu J*, and Zhang R* (2018) Structural basis of KANK1/KIF21A complex in crosstalk between dynamic microtubule and cell cortex. J Biol Chem 293(1):215-225. (Lead contact).

 

5. Zhu J#, Zhou Q#, Shang Y, Peng M, Weng Z, Zhang R, Huang X, Li S, Feng G, Zhang M*. (2017) Synaptic targeting and function of SAPAPs mediated by phosphorylation-dependent binding to PSD-95 MAGUKs. Cell Rep 21(13):3781-3793.

 

6. Xia Y#, Shang Y#, Zhang R, and Zhu J* (2017) Structure of PSD95/MAP1A complex reveals unique target recognition mode of MAGUK GK domain. Biochem J 474(16):2817-2828.

 

7. Zhu J#*, Shang Y#, Xia Y, Zhang R, Zhang M* (2016) An Atypical MAGUK GK Target Recognition Mode Revealed by the Interaction between DLG and KIF13B. Structure 24(11):1876-1885.

 

8. Zhu J, Shang Y, and Zhang M* (2016) Mechanistic Basis of MAGUKs-organized Complexes in Synaptic Development and Signalling. Nat Rev Neurosci 17(4):209-23.

 

9. Zhu J#, Shang Y#, Wan Q, Xia Y, Chen J, Du Q, and Zhang M*. (2014) Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl. Cell Res 24:451–463.

 

10. Pan Z#, Zhu J#, Shang Y#, Wei Z, Jia M, Xia C, Wen W, Wang W*, Zhang M*. (2013) An auto-inhibited conformation of LGN reveals a distinct interaction mode between the GoLoco motifs and TPR motifs. Structure 21, 1007–1017.

 

11. Zhu J, Shang Y, Chen J, Zhang M*. (2012) Structure and function of GK domains of MAGUK family proteins. Front Biol 7(5): 379–396 (invited review, cover paper).

 

12. Zhu J#, Shang Y#, Xia C, Wang W, Wen W*, Zhang M*. (2011) Guanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein binding modules. EMBO J 30:4986–4997.

 

13. Zhu J#, Wen W#, Zheng Z, Shang Y, Wei Z, Xiao Z, Pan Z, Du Q*, Wang W*, Zhang M* (2011) LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gαi/LGN/NuMA pathways. Mol Cell 43: 418–431.

 

#并列第一作者 *通讯作者

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